MCMedicalCodingSoftware
E88.0

E88.0: Disorders of plasma-protein metabolism, not elsewhere classified

Non-billable headerICD-10-CM

E88.0 is a non-billable header ICD-10-CM code for disorders of plasma-protein metabolism, not elsewhere classified. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • monoclonal gammopathy (of undetermined significance) (D47.2)
  • polyclonal hypergammaglobulinemia (D89.0)
  • Waldenström macroglobulinemia (C88.00)

Excludes2: not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • disorder of lipoprotein metabolism (E78.-)

Excludes1 inherited from the categories above E88.0

A category’s note binds every code beneath it.

Written on E88: Other and unspecified metabolic disorders

  • histiocytosis X (chronic) (C96.6)

Other codes that can never be billed with E88.0

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • R77Other abnormalities of plasma proteins

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead E88.0

3 child codes. Green means billable.

Other codes under E88

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.