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C88.00

C88.00Waldenstrom macroglobulinemia not having achieved remission

Billable / specific codeICD-10-CM

C88.00 is a billable, specific ICD-10-CM code for waldenstrom macroglobulinemia not having achieved remission. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Lymphoplasmacytic lymphoma with IgM-production, NOS
  • Lymphoplasmacytic lymphoma with IgM-production not having achieved remission
  • Lymphoplasmacytic lymphoma with IgM-production with failed remission
  • Macroglobulinemia (idiopathic) (primary) NOS
  • Macroglobulinemia (idiopathic) (primary) not having achieved remission
  • Macroglobulinemia (idiopathic) (primary) with failed remission
  • Waldenström macroglobulinemia NOS
  • Waldenström macroglobulinemia with failed remission

Excludes1 inherited from the categories above C88.00

These are not written on C88.00, but they bind it: a note on a category applies to every code beneath it. Billing C88.00 with anything listed here is a denial.

Written on C88.0 Waldenstrom macroglobulinemia

  • small cell B-cell lymphoma (C83.0)

Written on C88 Malignant immunoproliferative diseases and certain other B-cell lymphomas

  • B-cell lymphoma, unspecified (C85.1-)
  • personal history of other malignant neoplasms of lymphoid, hematopoietic and related tissues (Z85.79)

Other codes that can never be billed with C88.00

These codes carry an Excludes1 note pointing at C88.00. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading C88.00 alone.

  • E88.0Disorders of plasma-protein metabolism, not elsewhere classified
  • C83.0Small cell B-cell lymphoma

Risk adjustment

C88.00 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 21 Lymphoma and Other Cancers0.671 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

C88.00 is named in 40 Medicare coverage policies 40 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

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  • A52986Billing and Coding: Biomarkers for Oncology

Code history

What changed, and when. Derived by diffing consecutive CMS release files — which matters when you are defending a code assigned under an earlier edition.

  • addedFY2024-FY2026

    Waldenstrom macroglobulinemia not having achieved remission

Related codes at this level

Codes that share C88.0. If C88.00 is not quite right, the correct code is usually one of these.

Questions about C88.00

Is C88.00 a billable ICD-10-CM code?
Yes. C88.00 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does C88.00 sit in the tabular list?
Neoplasms (C00-D49), in the block Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96).
What cannot be coded together with C88.00?
C88.00 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above C88.00 (C88.0, C88) and apply to it just the same.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.