E88.3

E88.3: Tumor lysis syndrome

Billable / specific codeICD-10-CM

E88.3 is a billable, specific ICD-10-CM code for tumor lysis syndrome. It is valid for submission on a claim.

Check E88.3 with the rest of the claim: free scrubber

Use additional code

Add a secondary code to capture the detail described below.

code for adverse effect, if applicable, to identify drug (T45.1X5)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

Tumor lysis syndrome (spontaneous)
Tumor lysis syndrome following antineoplastic drug chemotherapy

Excludes1 inherited from the categories above E88.3

A category’s note binds every code beneath it.

Written on E88: Other and unspecified metabolic disorders

histiocytosis X (chronic) (C96.6)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E88.3 is named in 3 Medicare coverage policies: 3 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

A56421Billing and Coding: CT of the Abdomen and Pelvis
A56717Billing and Coding: Respiratory Therapy (Respiratory Care)
A57224Billing and Coding: Respiratory Care

Alphabetic index entries that lead here

Tumor lysis syndrome NEC(following antineoplastic chemotherapy) (spontaneous)
Syndrome›tumor lysis NEC(following antineoplastic chemotherapy) (spontaneous)

Code history

Unchanged in every release from FY2024 to FY2027.