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E22.0

E22.0: Acromegaly and pituitary gigantism

Billable / specific codeICD-10-CM

E22.0 is a billable, specific ICD-10-CM code for acromegaly and pituitary gigantism. It is valid for submission on a claim.

Check E22.0 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • constitutional gigantism (E34.4)
  • constitutional tall stature (E34.4)
  • increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Overproduction of growth hormone

Excludes1 inherited from the categories above E22.0

A category’s note binds every code beneath it.

Written on E22: Hyperfunction of pituitary gland

  • Cushing's syndrome (E24.-)
  • Nelson's syndrome (E24.1)
  • overproduction of ACTH not associated with Cushing's disease (E27.0)
  • overproduction of pituitary ACTH (E24.0)
  • overproduction of thyroid-stimulating hormone (E05.8-)

Other codes that can never be billed with E22.0

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • M26.0Major anomalies of jaw size

Risk adjustment

E22.0 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 51 Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders0.510 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score. Look up the whole chart to see which of its HCCs the hierarchy would zero.

Medicare coverage

E22.0 is named in 8 Medicare coverage policies: 8 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56531Billing and Coding: Octreotide Acetate for Injectable Suspension (Sandostatin® LAR Depot)
  • A56551Billing and Coding: Visual Fields Testing
  • A56612Billing and Coding: CT of the Head
  • A56631Billing and Coding: Thoracic Aortography and Carotid, Vertebral, and Subclavian Angiography

Alphabetic index entries that lead here

  • Acromegaly, acromegalia
  • Erdheim's syndrome(acromegalic macrospondylitis)
  • Gigantism(cerebral) (hypophyseal) (pituitary)
  • Launois' syndrome(pituitary gigantism)
  • Macrospondylitis , acromegalic
  • Scaglietti-Dagnini syndrome
  • Hypophyseal, hypophysis›gigantism
  • Marie's›disease or syndrome(acromegaly)
  • Overproduction›growth hormone
  • Syndrome›costovertebral
  • Syndrome›Erdheim's
  • Syndrome›Launois'

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E22

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.