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E22

E22: Hyperfunction of pituitary gland

Non-billable headerICD-10-CM

E22 is a non-billable header ICD-10-CM code for hyperfunction of pituitary gland. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • Cushing's syndrome (E24.-)
  • Nelson's syndrome (E24.1)
  • overproduction of ACTH not associated with Cushing's disease (E27.0)
  • overproduction of pituitary ACTH (E24.0)
  • overproduction of thyroid-stimulating hormone (E05.8-)

Other codes that can never be billed with E22

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E30.1Precocious puberty
  • E87.1Hypo-osmolality and hyponatremia
  • M26.0Major anomalies of jaw size

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead E22

5 child codes. Green means billable.

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.