Is E22 a billable ICD-10-CM code?

No. E22 is a non-billable header code. Code to a higher level of specificity using one of its child codes.

Where does E22 sit in the tabular list?

Endocrine, nutritional and metabolic diseases (E00-E89), in the block Disorders of other endocrine glands (E20-E35).

What cannot be coded together with E22?

E22 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.

E22

E22 — Hyperfunction of pituitary gland

Non-billable headerICD-10-CM

E22 is a non-billable header ICD-10-CM code for hyperfunction of pituitary gland. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

Cushing's syndrome (E24.-)
Nelson's syndrome (E24.1)
overproduction of ACTH not associated with Cushing's disease (E27.0)
overproduction of pituitary ACTH (E24.0)
overproduction of thyroid-stimulating hormone (E05.8-)

Other codes that can never be billed with E22

These codes carry an Excludes1 note pointing at E22. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading E22 alone.

M26.0Major anomalies of jaw size
E87.1Hypo-osmolality and hyponatremia
E30.1Precocious puberty

Risk adjustment

E22 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Code to one of these instead E22

5 child codes. Green means billable.

Questions about E22

Is E22 a billable ICD-10-CM code?: No. E22 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does E22 sit in the tabular list?: Endocrine, nutritional and metabolic diseases (E00-E89), in the block Disorders of other endocrine glands (E20-E35).
What cannot be coded together with E22?: E22 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.