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E22.8

E22.8Other hyperfunction of pituitary gland

Billable / specific codeICD-10-CM

E22.8 is a billable, specific ICD-10-CM code for other hyperfunction of pituitary gland. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Central precocious puberty

Other codes that can never be billed with E22.8

These codes carry an Excludes1 note pointing at E22.8. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading E22.8 alone.

Risk adjustment

E22.8 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

E22.8 is named in 11 Medicare coverage policies 11 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52453Billing and Coding: Luteinizing Hormone-Releasing Hormone (LHRH) Analogs
  • A56551Billing and Coding: Visual Fields Testing
  • A56612Billing and Coding: CT of the Head
  • A56631Billing and Coding: Thoracic Aortography and Carotid, Vertebral, and Subclavian Angiography

How E22.8 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E22.8.

  • Hyperfunctionpituitaryspecified NEC
  • Precociouspubertycentral
  • Pubertyprecociouscentral
  • Pubertyprematuredue topituitary hyperfunction(anterior)

Related codes at this level

Codes that share E22. If E22.8 is not quite right, the correct code is usually one of these.

Questions about E22.8

Is E22.8 a billable ICD-10-CM code?
Yes. E22.8 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E22.8 sit in the tabular list?
Endocrine, nutritional and metabolic diseases (E00-E89), in the block Disorders of other endocrine glands (E20-E35).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.