MCMedicalCodingSoftware
E22.2

E22.2: Syndrome of inappropriate secretion of antidiuretic hormone

Billable / specific codeICD-10-CM

E22.2 is a billable, specific ICD-10-CM code for syndrome of inappropriate secretion of antidiuretic hormone. It is valid for submission on a claim.

Check E22.2 with the rest of the claim: free scrubber

Excludes1 inherited from the categories above E22.2

A category’s note binds every code beneath it.

Written on E22: Hyperfunction of pituitary gland

  • Cushing's syndrome (E24.-)
  • Nelson's syndrome (E24.1)
  • overproduction of ACTH not associated with Cushing's disease (E27.0)
  • overproduction of pituitary ACTH (E24.0)
  • overproduction of thyroid-stimulating hormone (E05.8-)

Other codes that can never be billed with E22.2

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E87.1Hypo-osmolality and hyponatremia

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E22.2 is named in 8 Medicare coverage policies: 8 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56551Billing and Coding: Visual Fields Testing
  • A56612Billing and Coding: CT of the Head
  • A56631Billing and Coding: Thoracic Aortography and Carotid, Vertebral, and Subclavian Angiography
  • A56799Billing and Coding: Visual Fields Testing

Alphabetic index entries that lead here

  • Antidiuretic hormone syndrome
  • Schwartz-Bartter syndrome
  • Secretion›antidiuretic hormone, inappropriate
  • Syndrome›inappropriate secretion of antidiuretic hormone
  • Syndrome›Schwartz-Bartter
  • Hypersecretion›hormone›antidiuretic
  • Inappropriate›secretion›antidiuretic hormone(ADH) (excessive)
  • Inappropriate›secretion›pituitary(posterior)
  • Secretion›hormone›antidiuretic, inappropriate(syndrome)
  • Increase, increased›function›pituitary›posterior
  • Perversion, perverted›function›pituitary gland›posterior lobe

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E22

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.