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E22.1

E22.1: Hyperprolactinemia

Billable / specific codeICD-10-CM

E22.1 is a billable, specific ICD-10-CM code for hyperprolactinemia. It is valid for submission on a claim.

Check E22.1 with the rest of the claim: free scrubber

Use additional code

Add a secondary code to capture the detail described below.

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Excludes1 inherited from the categories above E22.1

A category’s note binds every code beneath it.

Written on E22: Hyperfunction of pituitary gland

  • Cushing's syndrome (E24.-)
  • Nelson's syndrome (E24.1)
  • overproduction of ACTH not associated with Cushing's disease (E27.0)
  • overproduction of pituitary ACTH (E24.0)
  • overproduction of thyroid-stimulating hormone (E05.8-)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E22.1 is named in 7 Medicare coverage policies: 7 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56551Billing and Coding: Visual Fields Testing
  • A56612Billing and Coding: CT of the Head
  • A56631Billing and Coding: Thoracic Aortography and Carotid, Vertebral, and Subclavian Angiography
  • A56799Billing and Coding: Visual Fields Testing

Alphabetic index entries that lead here

  • Hyperprolactinemia

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E22

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.