MCMedicalCodingSoftware
E16.8

E16.8: Other specified disorders of pancreatic internal secretion

Billable / specific codeICD-10-CM

E16.8 is a billable, specific ICD-10-CM code for other specified disorders of pancreatic internal secretion. It is valid for submission on a claim.

Check E16.8 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Increased secretion from endocrine pancreas of growth hormone-releasing hormone
  • Increased secretion from endocrine pancreas of pancreatic polypeptide
  • Increased secretion from endocrine pancreas of somatostatin
  • Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide

Other codes that can never be billed with E16.8

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E22.0Acromegaly and pituitary gigantism

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E16.8 is named in 3 Medicare coverage policies: 3 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52479Oral Anticancer Drugs - Policy Article
  • A56421Billing and Coding: CT of the Abdomen and Pelvis
  • A57361Billing and Coding: Monitored Anesthesia Care

Alphabetic index entries that lead here

  • Disorder›pancreatic internal secretion›specified NEC
  • Hyperplasia, hyperplastic›pancreatic islet cells›alpha
  • Increase, increased›secretion›pancreas, endocrine›growth hormone-releasing hormone
  • Increase, increased›secretion›pancreas, endocrine›pancreatic polypeptide
  • Increase, increased›secretion›pancreas, endocrine›somatostatin
  • Increase, increased›secretion›pancreas, endocrine›vasoactive-intestinal polypeptide

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E16

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.