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E16.4

E16.4: Increased secretion of gastrin

Billable / specific codeICD-10-CM

E16.4 is a billable, specific ICD-10-CM code for increased secretion of gastrin. It is valid for submission on a claim.

Check E16.4 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Hypergastrinemia
  • Hyperplasia of pancreatic endocrine cells with gastrin excess
  • Zollinger-Ellison syndrome

Other codes that can never be billed with E16.4

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • K29Gastritis and duodenitis

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E16.4 is named in 7 Medicare coverage policies: 7 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56421Billing and Coding: CT of the Abdomen and Pelvis
  • A57063Billing and Coding: Diagnostic and Therapeutic Esophagogastroduodenoscopy
  • A57361Billing and Coding: Monitored Anesthesia Care
  • A57753Billing and Coding: Wireless Capsule Endoscopy

Alphabetic index entries that lead here

  • Ellison-Zollinger syndrome
  • Hypergastrinemia
  • Zollinger-Ellison syndrome
  • Abnormal, abnormality, abnormalities›gastrin secretion
  • Hypersecretion›gastrin
  • Abnormal, abnormality, abnormalities›secretion›gastrin
  • Increase, increased›secretion›gastrin
  • Hyperplasia, hyperplastic›pancreatic islet cells›alpha›with excess›gastrin

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E16

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.