MCMCB Pro
D81.819

D81.819Biotin-dependent carboxylase deficiency, unspecified

Billable / specific codeICD-10-CM

D81.819 is a billable, specific ICD-10-CM code for biotin-dependent carboxylase deficiency, unspecified. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Multiple carboxylase deficiency, unspecified

Risk adjustment

D81.819 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D81.819 is named in 6 Medicare coverage policies 6 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52996Billing and Coding: Routine Foot Care
  • A56416Billing and Coding: Assays for Vitamins and Metabolic Function
  • A57188Billing and Coding: Routine Foot Care
  • A57188Billing and Coding: Routine Foot Care

How D81.819 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D81.819.

  • Deficiency, deficientbiotin-dependent carboxylase
  • Immunodeficiencycombinedbiotin-dependent carboxylase

Related codes at this level

Codes that share D81.81. If D81.819 is not quite right, the correct code is usually one of these.

Questions about D81.819

Is D81.819 a billable ICD-10-CM code?
Yes. D81.819 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D81.819 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.