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D81.819

D81.819: Biotin-dependent carboxylase deficiency, unspecified

Billable / specific codeICD-10-CM

D81.819 is a billable, specific ICD-10-CM code for biotin-dependent carboxylase deficiency, unspecified. It is valid for submission on a claim.

Check D81.819 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Multiple carboxylase deficiency, unspecified

Excludes1 inherited from the categories above D81.819

A category’s note binds every code beneath it.

Written on D81.81: Biotin-dependent carboxylase deficiency

  • biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)

Written on D81: Combined immunodeficiencies

  • autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

Other codes that can never be billed with D81.819

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E79Disorders of purine and pyrimidine metabolism

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

D81.819 is named in 5 Medicare coverage policies: 5 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52996Billing and Coding: Routine Foot Care
  • A56416Billing and Coding: Assays for Vitamins and Metabolic Function
  • A57188Billing and Coding: Routine Foot Care
  • A57755Billing and Coding: Vitamin B<sub>12</sub> Injections

Alphabetic index entries that lead here

  • Deficiency, deficient›biotin-dependent carboxylase
  • Immunodeficiency›combined›biotin-dependent carboxylase

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D81.81

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.