Is D81.810 a billable ICD-10-CM code?

Yes. D81.810 is a billable, specific ICD-10-CM code and is valid for submission on a claim.

Where does D81.810 sit in the tabular list?

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).

What cannot be coded together with D81.810?

D81.810 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above D81.810 (D81.81, D81) and apply to it just the same.

D81.810

D81.810 — Biotinidase deficiency

Billable / specific codeICD-10-CM

D81.810 is a billable, specific ICD-10-CM code for biotinidase deficiency. It is valid for submission on a claim.

Excludes1 inherited from the categories above D81.810

These are not written on D81.810, but they bind it: a note on a category applies to every code beneath it. Billing D81.810 with anything listed here is a denial.

Written on D81.81 — Biotin-dependent carboxylase deficiency

biotin-dependent carboxylase deficiency due to dietary deficiency of biotin (E53.8)

Written on D81 — Combined immunodeficiencies

autosomal recessive agammaglobulinemia (Swiss type) (D80.0)

Other codes that can never be billed with D81.810

These codes carry an Excludes1 note pointing at D81.810. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D81.810 alone.

E79Disorders of purine and pyrimidine metabolism

Risk adjustment

D81.810 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D81.810 is named in 16 Medicare coverage policies — 16 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

A56638Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs)
A56642Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs)
A57205Billing and Coding: Oximetry Services
A57224Billing and Coding: Respiratory Care

How D81.810 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D81.810.

Deficiency, deficient›biotinidase
Immunodeficiency›combined›biotin-dependent carboxylase›biotinidase

Code history

D81.810 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share D81.81. If D81.810 is not quite right, the correct code is usually one of these.

Questions about D81.810

Is D81.810 a billable ICD-10-CM code?: Yes. D81.810 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D81.810 sit in the tabular list?: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).
What cannot be coded together with D81.810?: D81.810 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above D81.810 (D81.81, D81) and apply to it just the same.