D81
D81 — Combined immunodeficiencies
Non-billable headerICD-10-CM
D81 is a non-billable header ICD-10-CM code for combined immunodeficiencies. It cannot be billed on its own: choose one of the more specific child codes below.
Excludes1 — never code together
These conditions cannot occur together. Billing both on the same encounter is a denial.
- autosomal recessive agammaglobulinemia (Swiss type) (D80.0)
Other codes that can never be billed with D81
These codes carry an Excludes1 note pointing at D81. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D81 alone.
- E79Disorders of purine and pyrimidine metabolism
Risk adjustment
D81 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.
Code to one of these instead D81
10 child codes. Green means billable.
- D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesis
- D81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
- D81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
- D81.3Adenosine deaminase [ADA] deficiency
- D81.4Nezelof's syndrome
- D81.5Purine nucleoside phosphorylase [PNP] deficiency
- D81.6Major histocompatibility complex class I deficiency
- D81.7Major histocompatibility complex class II deficiency
- D81.8Other combined immunodeficiencies
- D81.9Combined immunodeficiency, unspecified
Questions about D81
- Is D81 a billable ICD-10-CM code?
- No. D81 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
- Where does D81 sit in the tabular list?
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).
- What cannot be coded together with D81?
- D81 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.