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ICD-10-CM tabular list

Chapter 3: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

D50-D89

Chapter 3 of the ICD-10-CM tabular list covers diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, codes D50-D89. It holds 401 codes across 7 blocks, of which 323 are billable and 78 are header codes that cannot go on a claim.

Excludes2 — not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

Risk adjustment in Chapter 3

141 of this chapter’s codes map to a CMS-HCC, which means the diagnosis carries a risk-adjustment payment when it is documented and coded to the level the record supports.

  • HCC 108 Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major
  • HCC 109 Acquired Hemolytic, Aplastic, and Sideroblastic Anemias
  • HCC 112 Immune Thrombocytopenia and Specified Coagulation Defects and Hemorrhagic Conditions
  • HCC 115 Specified Immunodeficiencies and White Blood Cell Disorders
  • HCC 114 Common Variable and Combined Immunodeficiencies
  • HCC 107 Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero

Blocks in this chapter

ICD-10-CMFY2026-Apr· effective April 1, 2026