MCMedicalCodingSoftware
Z16.2

Z16.2: Resistance to other antibiotics

Non-billable headerICD-10-CM

Z16.2 is a non-billable header ICD-10-CM code for resistance to other antibiotics. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1 inherited from the categories above Z16.2

A category’s note binds every code beneath it.

Written on Z16: Resistance to antimicrobial drugs

  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Other codes that can never be billed with Z16.2

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • Z16.3Resistance to other antimicrobial drugs
  • Z16.35Resistance to multiple antimicrobial drugs

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead Z16.2

6 child codes. Green means billable.

Other codes under Z16

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.