MCMedicalCodingSoftware
Z16.35

Z16.35: Resistance to multiple antimicrobial drugs

Billable / specific codeICD-10-CM

Z16.35 is a billable, specific ICD-10-CM code for resistance to multiple antimicrobial drugs. It is valid for submission on a claim.

Check Z16.35 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • Resistance to multiple antibiotics only (Z16.24)

Excludes1 inherited from the categories above Z16.35

A category’s note binds every code beneath it.

Written on Z16.3: Resistance to other antimicrobial drugs

Written on Z16: Resistance to antimicrobial drugs

  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Alphabetic index entries that lead here

  • Resistance, resistant›organism›to›drug›antimicrobial›multiple
  • Resistance, resistant›organism›to›drug›multiple drugs›antimicrobial

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under Z16.3

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.