Z16.1 — Resistance to beta lactam antibiotics
Z16.1 is a non-billable header ICD-10-CM code for resistance to beta lactam antibiotics. It cannot be billed on its own: choose one of the more specific child codes below.
Excludes1 inherited from the categories above Z16.1
These are not written on Z16.1, but they bind it: a note on a category applies to every code beneath it. Billing Z16.1 with anything listed here is a denial.
Other codes that can never be billed with Z16.1
These codes carry an Excludes1 note pointing at Z16.1. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading Z16.1 alone.
- Z16.3Resistance to other antimicrobial drugs
Risk adjustment
Z16.1 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.
Code history
Z16.1 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.
Code to one of these instead Z16.1
5 child codes. Green means billable.
Related codes at this level
Codes that share Z16. If Z16.1 is not quite right, the correct code is usually one of these.
Questions about Z16.1
- Is Z16.1 a billable ICD-10-CM code?
- No. Z16.1 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
- Where does Z16.1 sit in the tabular list?
- Factors influencing health status and contact with health services (Z00-Z99), in the block Resistance to antimicrobial drugs (Z16).
- What cannot be coded together with Z16.1?
- Z16.1 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above Z16.1 (Z16) and apply to it just the same.