MCMedicalCodingSoftware
Z16.3

Z16.3: Resistance to other antimicrobial drugs

Non-billable headerICD-10-CM

Z16.3 is a non-billable header ICD-10-CM code for resistance to other antimicrobial drugs. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

Excludes1 inherited from the categories above Z16.3

A category’s note binds every code beneath it.

Written on Z16: Resistance to antimicrobial drugs

  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead Z16.3

7 child codes. Green means billable.

Other codes under Z16

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.