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Z16

Z16: Resistance to antimicrobial drugs

Non-billable headerICD-10-CM

Z16 is a non-billable header ICD-10-CM code for resistance to antimicrobial drugs. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code first

The underlying condition must be sequenced before this code.

  • the infection

Notes

Additional guidance from the ICD-10-CM tabular list.

  • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Other codes that can never be billed with Z16

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • Z16.3Resistance to other antimicrobial drugs
  • Z16.35Resistance to multiple antimicrobial drugs

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead Z16

3 child codes. Green means billable.

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.