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Z16.21

Z16.21: Resistance to vancomycin

Billable / specific codeICD-10-CM

Z16.21 is a billable, specific ICD-10-CM code for resistance to vancomycin. It is valid for submission on a claim.

Check Z16.21 with the rest of the claim: free scrubber

Excludes1 inherited from the categories above Z16.21

A category’s note binds every code beneath it.

Written on Z16: Resistance to antimicrobial drugs

  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Alphabetic index entries that lead here

  • Resistance, resistant›organism›to›drug›vancomycin

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under Z16.2

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.