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E74.4

E74.4: Disorders of pyruvate metabolism and gluconeogenesis

Billable / specific codeICD-10-CM

E74.4 is a billable, specific ICD-10-CM code for disorders of pyruvate metabolism and gluconeogenesis. It is valid for submission on a claim.

Check E74.4 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)
  • Leigh's syndrome (G31.82)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Deficiency of phosphoenolpyruvate carboxykinase
  • Deficiency of pyruvate carboxylase
  • Deficiency of pyruvate dehydrogenase

Excludes1 inherited from the categories above E74.4

A category’s note binds every code beneath it.

Written on E74: Other disorders of carbohydrate metabolism

Other codes that can never be billed with E74.4

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E88.4Mitochondrial metabolism disorders

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E74.4 is named in 1 Medicare coverage policy: 1 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52850Billing and Coding: Cardiac Catheterization and Coronary Angiography

Alphabetic index entries that lead here

  • Deficiency, deficient›phosphoenolpyruvate carboxykinase
  • Disorder›gluconeogenesis
  • Disorder›pyruvate metabolism
  • Deficiency, deficient›pyruvate›carboxylase
  • Deficiency, deficient›pyruvate›dehydrogenase
  • Disorder›metabolism NOS›pyruvate

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E74

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.