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E74.05

E74.05Lysosome-associated membrane protein 2 [LAMP2] deficiency

Billable / specific codeICD-10-CM

E74.05 is a billable, specific ICD-10-CM code for lysosome-associated membrane protein 2 [lamp2] deficiency. It is valid for submission on a claim.

Code also

Both codes may be needed to describe the encounter fully. Sequencing depends on the reason for the visit.

  • , if applicable, associated manifestations such as:
  • dilated cardiomyopathy (I42.0)
  • obstructive hypertrophic cardiomyopathy (I42.1)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Danon disease

Risk adjustment

E74.05 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 50 Amyloidosis, Porphyria, and Other Specified Metabolic Disorders0.648 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

E74.05 is named in 10 Medicare coverage policies 10 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52494High Frequency Chest Wall Oscillation Devices - Policy Article
  • A52510Mechanical In-exsufflation Devices - Policy Article
  • A52850Billing and Coding: Cardiac Catheterization and Coronary Angiography
  • A52850Billing and Coding: Cardiac Catheterization and Coronary Angiography

How E74.05 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E74.05.

  • Deficiency, deficientlysosome-associated membrane protein 2 [LAMP2]
  • Disease, diseasedAntopol
  • Disease, diseasedDanon
  • Disease, diseasedglycogen storagetype IIB
  • Disease, diseasedglycogen storagelysosomalwithout acid maltase deficiency

Related codes at this level

Codes that share E74.0. If E74.05 is not quite right, the correct code is usually one of these.

Questions about E74.05

Is E74.05 a billable ICD-10-CM code?
Yes. E74.05 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E74.05 sit in the tabular list?
Endocrine, nutritional and metabolic diseases (E00-E89), in the block Metabolic disorders (E70-E88).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.