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D80.1

D80.1Nonfamilial hypogammaglobulinemia

Billable / specific codeICD-10-CM

D80.1 is a billable, specific ICD-10-CM code for nonfamilial hypogammaglobulinemia. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes
  • Common variable agammaglobulinemia [CVAgamma]
  • Hypogammaglobulinemia NOS

Risk adjustment

D80.1 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D80.1 is named in 31 Medicare coverage policies 31 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A55717Billing and Coding: Lab: Flow Cytometry
  • A56464Billing and Coding: Flow Cytometry
  • A56638Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs)
  • A56642Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs)

How D80.1 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D80.1.

  • Agammaglobulinemia(acquired (secondary)) (nonfamilial)
  • Hypogammaglobulinemia
  • Absencegamma globulin in blood
  • Agammaglobulinemiacommon variable(CVAgamma)
  • Deficiency, deficientgammaglobulin in blood
  • Hypogammaglobulinemianonfamilial
  • Agammaglobulinemiawithimmunoglobulin-bearing B-lymphocytes
  • Arthritis, arthriticinhypogammaglobulinemia
  • Syndromeantibody deficiencyagammaglobulinemic
  • Syndromeantibody deficiencyhypogammaglobulinemic
  • Disease, diseasedconnective tissue, systemicinhypogammaglobulinemia

Related codes at this level

Codes that share D80. If D80.1 is not quite right, the correct code is usually one of these.

Questions about D80.1

Is D80.1 a billable ICD-10-CM code?
Yes. D80.1 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D80.1 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.