Is D57.451 a billable ICD-10-CM code?

Yes. D57.451 is a billable, specific ICD-10-CM code and is valid for submission on a claim.

Where does D57.451 sit in the tabular list?

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Hemolytic anemias (D55-D59).

What cannot be coded together with D57.451?

D57.451 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above D57.451 (D57) and apply to it just the same.

D57.451

D57.451 — Sickle-cell thalassemia beta plus with acute chest syndrome

Billable / specific codeICD-10-CM

D57.451 is a billable, specific ICD-10-CM code for sickle-cell thalassemia beta plus with acute chest syndrome. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

HbS-beta plus with acute chest syndrome
Sickle-cell beta plus with acute chest syndrome

Excludes1 inherited from the categories above D57.451

These are not written on D57.451, but they bind it: a note on a category applies to every code beneath it. Billing D57.451 with anything listed here is a denial.

Written on D57 — Sickle-cell disorders

other hemoglobinopathies (D58.-)

Other codes that can never be billed with D57.451

These codes carry an Excludes1 note pointing at D57.451. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D57.451 alone.

D56.8Other thalassemias

Risk adjustment

D57.451 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

HCC 108 Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major0.146 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

D57.451 is named in 15 Medicare coverage policies — 15 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

A55717Billing and Coding: Lab: Flow Cytometry
A56464Billing and Coding: Flow Cytometry
A56580Billing and Coding: Computerized Axial Tomography (CT), Thorax
A56697Billing and Coding: Non-Invasive Vascular Studies

How D57.451 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D57.451.

Disease, diseased›hemoglobin or Hb›S or SS›beta plus›with›acute chest syndrome
Disease, diseased›sickle-cell›thalassemia›beta plus›with›acute chest syndrome

Code history

D57.451 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share D57.45. If D57.451 is not quite right, the correct code is usually one of these.

Questions about D57.451

Is D57.451 a billable ICD-10-CM code?: Yes. D57.451 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D57.451 sit in the tabular list?: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Hemolytic anemias (D55-D59).
What cannot be coded together with D57.451?: D57.451 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above D57.451 (D57) and apply to it just the same.