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D57.4

D57.4Sickle-cell thalassemia

Non-billable headerICD-10-CM

D57.4 is a non-billable header ICD-10-CM code for sickle-cell thalassemia. It cannot be billed on its own: choose one of the more specific child codes below.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Sickle-cell beta thalassemia
  • Thalassemia Hb-S disease

Other codes that can never be billed with D57.4

These codes carry an Excludes1 note pointing at D57.4. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D57.4 alone.

  • D56Thalassemia
  • D56.1Beta thalassemia
  • D56.5Hemoglobin E-beta thalassemia
  • D56.8Other thalassemias

Risk adjustment

D57.4 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Code to one of these instead D57.4

6 child codes. Green means billable.

Related codes at this level

Codes that share D57. If D57.4 is not quite right, the correct code is usually one of these.

Questions about D57.4

Is D57.4 a billable ICD-10-CM code?
No. D57.4 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does D57.4 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Hemolytic anemias (D55-D59).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.