MCMCB Pro
D57.412

D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration

Billable / specific codeICD-10-CM

D57.412 is a billable, specific ICD-10-CM code for sickle-cell thalassemia, unspecified, with splenic sequestration. It is valid for submission on a claim.

Risk adjustment

D57.412 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 108 Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major0.146 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

D57.412 is named in 14 Medicare coverage policies 14 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A55717Billing and Coding: Lab: Flow Cytometry
  • A56421Billing and Coding: CT of the Abdomen and Pelvis
  • A56464Billing and Coding: Flow Cytometry
  • A56580Billing and Coding: Computerized Axial Tomography (CT), Thorax

How D57.412 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D57.412.

  • Microdrepanocytosiswithsplenic sequestration
  • Disease, diseasedsickle-cellthalassemiawithsplenic sequestration
  • Hemoglobinopathysickle-cellwith thalassemiawithsplenic sequestration

Related codes at this level

Codes that share D57.41. If D57.412 is not quite right, the correct code is usually one of these.

Questions about D57.412

Is D57.412 a billable ICD-10-CM code?
Yes. D57.412 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D57.412 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Hemolytic anemias (D55-D59).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.