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D56.4

D56.4: Hereditary persistence of fetal hemoglobin [HPFH]

Billable / specific codeICD-10-CM

D56.4 is a billable, specific ICD-10-CM code for hereditary persistence of fetal hemoglobin [hpfh]. It is valid for submission on a claim.

Check D56.4 with the rest of the claim: free scrubber

Excludes1 inherited from the categories above D56.4

A category’s note binds every code beneath it.

Written on D56: Thalassemia

  • sickle-cell thalassemia (D57.4-)

Other codes that can never be billed with D56.4

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • D58.2Other hemoglobinopathies

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

D56.4 is named in 4 Medicare coverage policies: 4 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A55717Billing and Coding: Lab: Flow Cytometry
  • A56464Billing and Coding: Flow Cytometry
  • A56718Billing and Coding: Intravenous Immunoglobulin (IVIG)
  • A57689Billing and Coding: Lab: Flow Cytometry

Alphabetic index entries that lead here

  • Hemoglobin›fetal, hereditary persistence(HPFH)
  • Persistence, persistent›hemoglobin, fetal(hereditary) (HPFH)
  • Persistence, persistent›fetal›hemoglobin, hereditary(HPFH)

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D56

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.