Is Z16.342 a billable ICD-10-CM code?

Yes. Z16.342 is a billable, specific ICD-10-CM code and is valid for submission on a claim.

Where does Z16.342 sit in the tabular list?

Factors influencing health status and contact with health services (Z00-Z99), in the block Resistance to antimicrobial drugs (Z16).

What cannot be coded together with Z16.342?

Z16.342 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above Z16.342 (Z16.3, Z16) and apply to it just the same.

Z16.342

Z16.342 — Resistance to multiple antimycobacterial drugs

Billable / specific codeICD-10-CM

Z16.342 is a billable, specific ICD-10-CM code for resistance to multiple antimycobacterial drugs. It is valid for submission on a claim.

Excludes1 inherited from the categories above Z16.342

These are not written on Z16.342, but they bind it: a note on a category applies to every code beneath it. Billing Z16.342 with anything listed here is a denial.

Written on Z16.3 — Resistance to other antimicrobial drugs

resistance to antibiotics (Z16.1-, Z16.2-)

Written on Z16 — Resistance to antimicrobial drugs

Methicillin resistant Staphylococcus aureus infection (A49.02)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Risk adjustment

Z16.342 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

How Z16.342 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to Z16.342.

Resistance, resistant›organism›to›drug›antimycobacterial›multiple
Resistance, resistant›organism›to›drug›multiple drugs›antimycobacterials
Resistance, resistant›organism›to›drug›tuberculostatics›multiple

Code history

Z16.342 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share Z16.34. If Z16.342 is not quite right, the correct code is usually one of these.

Z16.341Resistance to single antimycobacterial drug

Questions about Z16.342

Is Z16.342 a billable ICD-10-CM code?: Yes. Z16.342 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does Z16.342 sit in the tabular list?: Factors influencing health status and contact with health services (Z00-Z99), in the block Resistance to antimicrobial drugs (Z16).
What cannot be coded together with Z16.342?: Z16.342 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above Z16.342 (Z16.3, Z16) and apply to it just the same.