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T88.6

T88.6: Anaphylactic reaction due to adverse effect of correct drug or medicament properly administered

Non-billable headerICD-10-CM

T88.6 is a non-billable header ICD-10-CM code for anaphylactic reaction due to adverse effect of correct drug or medicament properly administered. It cannot be billed on its own: choose one of the more specific child codes below. This code also requires a 7th character before it is complete.

This code requires a 7th character

The appropriate 7th character is to be added to each code from category T88

A
initial encounter
D
subsequent encounter
S
sequela

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • anaphylactic reaction due to serum (T80.5-)
  • anaphylactic shock or reaction due to adverse food reaction (T78.0-)

Use additional code

Add a secondary code to capture the detail described below.

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
  • Anaphylactoid reaction NOS

Excludes2 inherited from the categories above T88.6

Not part of this code, but both may be coded when both are present.

Written on T88: Other complications of surgical and medical care, not elsewhere classified

  • complication following infusion, transfusion and therapeutic injection (T80.-)
  • complication following procedure NEC (T81.-)
  • complications of anesthesia in labor and delivery (O74.-)
  • complications of anesthesia in pregnancy (O29.-)
  • complications of anesthesia in puerperium (O89.-)
  • complications of devices, implants and grafts (T82-T85)
  • complications of obstetric surgery and procedure (O75.4)
  • dermatitis due to drugs and medicaments (L23.3, L24.4, L25.1, L27.0-L27.1)
  • poisoning and toxic effects of drugs and chemicals (T36-T65 with fifth or sixth character 1-4)
  • specified complications classified elsewhere

Other codes that can never be billed with T88.6

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • R57Shock, not elsewhere classified
  • T78.2Anaphylactic shock, unspecified
  • T78.2XXAAnaphylactic shock, unspecified, initial encounter
  • T78.2XXDAnaphylactic shock, unspecified, subsequent encounter
  • T78.2XXSAnaphylactic shock, unspecified, sequela
  • T79.4Traumatic shock
  • T79.4XXATraumatic shock, initial encounter
  • T79.4XXDTraumatic shock, subsequent encounter

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Alphabetic index entries that lead here

  • Shock›drug›due to correct substance properly administered
  • Allergy, allergic›shock›due to›adverse effect of correct medicinal substance properly administered
  • Shock›anaphylactic›due to drug or medicinal substance›correct substance properly administered

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead T88.6

3 child codes. Green means billable.

Other codes under T88

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.