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L27.1

L27.1Localized skin eruption due to drugs and medicaments taken internally

Billable / specific codeICD-10-CM

L27.1 is a billable, specific ICD-10-CM code for localized skin eruption due to drugs and medicaments taken internally. It is valid for submission on a claim.

Use additional code

Add a secondary code to capture the detail described below.

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Excludes1 inherited from the categories above L27.1

These are not written on L27.1, but they bind it: a note on a category applies to every code beneath it. Billing L27.1 with anything listed here is a denial.

Written on L27 Dermatitis due to substances taken internally

Excludes2 inherited from the categories above L27.1

Also inherited, and the opposite of Excludes1: these conditions are not part of L27.1, but a patient can have both, so you may code both.

Written on L27 Dermatitis due to substances taken internally

  • adverse food reaction, except dermatitis (T78.0-T78.1)
  • contact dermatitis (L23-L25)
  • drug photoallergic response (L56.1)
  • drug phototoxic response (L56.0)
  • urticaria (L50.-)

Other codes that can never be billed with L27.1

These codes carry an Excludes1 note pointing at L27.1. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading L27.1 alone.

  • T78.4Other and unspecified allergy

Risk adjustment

L27.1 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

L27.1 is named in 14 Medicare coverage policies 14 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A57181Billing and Coding: Allergy Testing
  • A57181Billing and Coding: Allergy Testing
  • A57473Billing and Coding: Allergy Testing
  • A57473Billing and Coding: Allergy Testing

How L27.1 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to L27.1.

  • Erythrodysesthesia, palmar plantar(PPE)
  • Hand-foot syndrome
  • Syndromehand-foot
  • Eruptiondrugfixed
  • Eruptiondruglocalized
  • Dermatitisdue todrugs and medicamentslocalized skin eruption
  • Eruptionskindue to inoculation/vaccinationlocalized

Code history

L27.1 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share L27. If L27.1 is not quite right, the correct code is usually one of these.

Questions about L27.1

Is L27.1 a billable ICD-10-CM code?
Yes. L27.1 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does L27.1 sit in the tabular list?
Diseases of the skin and subcutaneous tissue (L00-L99), in the block Dermatitis and eczema (L20-L30).
What cannot be coded together with L27.1?
L27.1 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above L27.1 (L27) and apply to it just the same.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.