T80.5

T80.5: Anaphylactic reaction due to serum

Non-billable headerICD-10-CM

T80.5 is a non-billable header ICD-10-CM code for anaphylactic reaction due to serum. It cannot be billed on its own: choose one of the more specific child codes below. This code also requires a 7th character before it is complete.

This code requires a 7th character

The appropriate 7th character is to be added to each code from category T80

A: initial encounter
D: subsequent encounter
S: sequela

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
allergic reaction or shock NOS (T78.2)
anaphylactic reaction or shock NOS (T78.2)
anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
other serum reaction (T80.6-)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

Allergic shock due to serum
Anaphylactic shock due to serum
Anaphylactoid reaction due to serum
Anaphylaxis due to serum

Excludes2 inherited from the categories above T80.5

Not part of this code, but both may be coded when both are present.

Written on T80: Complications following infusion, transfusion and therapeutic injection

bone marrow transplant rejection (T86.01)
febrile nonhemolytic transfusion reaction (R50.84)
fluid overload due to transfusion (E87.71)
posttransfusion purpura (D69.51)
transfusion associated circulatory overload (TACO) (E87.71)
transfusion (red blood cell) associated hemochromatosis (E83.111)
transfusion related acute lung injury (TRALI) (J95.84)

Other codes that can never be billed with T80.5

Their own Excludes1 notes name this code, so the conflict is not listed above.

R57Shock, not elsewhere classified
T78.2Anaphylactic shock, unspecified
T78.2XXAAnaphylactic shock, unspecified, initial encounter
T78.2XXDAnaphylactic shock, unspecified, subsequent encounter
T78.2XXSAnaphylactic shock, unspecified, sequela
T79.4Traumatic shock
T79.4XXATraumatic shock, initial encounter
T79.4XXDTraumatic shock, subsequent encounter

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead T80.5

3 child codes. Green means billable.