Is T80.5 a billable ICD-10-CM code?

No. T80.5 is a non-billable header code. Code to a higher level of specificity using one of its child codes.

Where does T80.5 sit in the tabular list?

Injury, poisoning and certain other consequences of external causes (S00-T88), in the block Complications of surgical and medical care, not elsewhere classified (T80-T88).

What cannot be coded together with T80.5?

T80.5 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter.

T80.5

T80.5 — Anaphylactic reaction due to serum

Non-billable headerICD-10-CM

T80.5 is a non-billable header ICD-10-CM code for anaphylactic reaction due to serum. It cannot be billed on its own: choose one of the more specific child codes below. This code also requires a 7th character before it is complete.

This code requires a 7th character

The appropriate 7th character is to be added to each code from category T80

A: initial encounter
D: subsequent encounter
S: sequela

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
allergic reaction or shock NOS (T78.2)
anaphylactic reaction or shock NOS (T78.2)
anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
other serum reaction (T80.6-)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

Allergic shock due to serum
Anaphylactic shock due to serum
Anaphylactoid reaction due to serum
Anaphylaxis due to serum

Excludes2 inherited from the categories above T80.5

Also inherited, and the opposite of Excludes1: these conditions are not part of T80.5, but a patient can have both, so you may code both.

Written on T80 — Complications following infusion, transfusion and therapeutic injection

bone marrow transplant rejection (T86.01)
febrile nonhemolytic transfusion reaction (R50.84)
fluid overload due to transfusion (E87.71)
posttransfusion purpura (D69.51)
transfusion associated circulatory overload (TACO) (E87.71)
transfusion (red blood cell) associated hemochromatosis (E83.111)
transfusion related acute lung injury (TRALI) (J95.84)

Other codes that can never be billed with T80.5

These codes carry an Excludes1 note pointing at T80.5. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading T80.5 alone.

R57Shock, not elsewhere classified
T78.2Anaphylactic shock, unspecified
T78.2XXAAnaphylactic shock, unspecified, initial encounter
T78.2XXDAnaphylactic shock, unspecified, subsequent encounter
T78.2XXSAnaphylactic shock, unspecified, sequela
T79.4Traumatic shock
T79.4XXATraumatic shock, initial encounter
T79.4XXDTraumatic shock, subsequent encounter

Risk adjustment

T80.5 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Code history

T80.5 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Code to one of these instead T80.5

3 child codes. Green means billable.

Related codes at this level

Codes that share T80. If T80.5 is not quite right, the correct code is usually one of these.

Questions about T80.5

Is T80.5 a billable ICD-10-CM code?: No. T80.5 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does T80.5 sit in the tabular list?: Injury, poisoning and certain other consequences of external causes (S00-T88), in the block Complications of surgical and medical care, not elsewhere classified (T80-T88).
What cannot be coded together with T80.5?: T80.5 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter.