MCMedicalCodingSoftware
T80.59

T80.59: Anaphylactic reaction due to other serum

Non-billable headerICD-10-CM

T80.59 is a non-billable header ICD-10-CM code for anaphylactic reaction due to other serum. It cannot be billed on its own: choose one of the more specific child codes below. This code also requires a 7th character before it is complete.

This code requires a 7th character

The appropriate 7th character is to be added to each code from category T80

A
initial encounter
D
subsequent encounter
S
sequela

Excludes1 inherited from the categories above T80.59

A category’s note binds every code beneath it.

Written on T80.5: Anaphylactic reaction due to serum

  • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
  • allergic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
  • other serum reaction (T80.6-)

Excludes2 inherited from the categories above T80.59

Not part of this code, but both may be coded when both are present.

Written on T80: Complications following infusion, transfusion and therapeutic injection

  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Alphabetic index entries that lead here

  • Allergy, allergic›serum›anaphylactic shock
  • Reaction›serum›anaphylactic(immediate)
  • Serum›allergy, allergic reaction›shock
  • Shock›anaphylactic›serum
  • Allergy, allergic›shock›due to›serum NEC
  • Complication›infusion›serum reaction›anaphylactic shock
  • Shock›anaphylactic›serum›specified NEC

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead T80.59

3 child codes. Green means billable.

Other codes under T80.5

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.