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E88.82

E88.82: Obesity due to disruption of MC4R pathway

Billable / specific codeICD-10-CM

E88.82 is a billable, specific ICD-10-CM code for obesity due to disruption of mc4r pathway. It is valid for submission on a claim.

Check E88.82 with the rest of the claim: free scrubber

Use additional code

Add a secondary code to capture the detail described below.

  • code, if applicable, to identify associated manifestations, such as polyphagia (R63.2)
  • code to identify body mass index (BMI), if known (Z68.-)

Excludes1 inherited from the categories above E88.82

A category’s note binds every code beneath it.

Written on E88: Other and unspecified metabolic disorders

  • histiocytosis X (chronic) (C96.6)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E88.82 is named in 5 Medicare coverage policies: 5 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A53060Billing and Coding: Ophthalmology: Extended Ophthalmoscopy and Fundus Photography
  • A56421Billing and Coding: CT of the Abdomen and Pelvis
  • A56500Billing and Coding: Cardiac Catheterization and Coronary Angiography
  • A56774Billing and Coding: Ophthalmic Angiography (Fluorescein and Indocyanine Green)

Alphabetic index entries that lead here

  • Obesity›due to›disruption of MC4R pathway
  • Obesity›due to›gene mutation›leptin(LEP)
  • Obesity›due to›gene mutation›leptin receptor(LEPR)
  • Obesity›due to›gene mutation›melanocortin 4 Receptor(MC4R)
  • Obesity›due to›gene mutation›nuclear receptor coactivator 1(NCOA1)
  • Obesity›due to›gene mutation›proopiomelanocortin(POMC)
  • Obesity›due to›gene mutation›proprotein convertase subtilisin/kexin type 1(PCSK1)
  • Obesity›due to›gene mutation›src homology 2B adaptor signaling protein(SH2B1)

Code history

  • addedFY2024-FY2027

    Obesity due to disruption of MC4R pathway

Other codes under E88.8

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.