MCMCB Pro
E88.82

E88.82Obesity due to disruption of MC4R pathway

Billable / specific codeICD-10-CM

E88.82 is a billable, specific ICD-10-CM code for obesity due to disruption of mc4r pathway. It is valid for submission on a claim.

Use additional code

Add a secondary code to capture the detail described below.

  • code, if applicable, to identify associated manifestations, such as polyphagia (R63.2)
  • code to identify body mass index (BMI), if known (Z68.-)

Risk adjustment

E88.82 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

E88.82 is named in 5 Medicare coverage policies 5 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A53060Billing and Coding: Ophthalmology: Extended Ophthalmoscopy and Fundus Photography
  • A56421Billing and Coding: CT of the Abdomen and Pelvis
  • A56500Billing and Coding: Cardiac Catheterization and Coronary Angiography
  • A56774Billing and Coding: Ophthalmic Angiography (Fluorescein and Indocyanine Green)

How E88.82 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E88.82.

  • Obesitydue todisruption of MC4R pathway
  • Obesitydue togene mutationleptin(LEP)
  • Obesitydue togene mutationleptin receptor(LEPR)
  • Obesitydue togene mutationmelanocortin 4 Receptor(MC4R)
  • Obesitydue togene mutationnuclear receptor coactivator 1(NCOA1)
  • Obesitydue togene mutationproopiomelanocortin(POMC)
  • Obesitydue togene mutationproprotein convertase subtilisin/kexin type 1(PCSK1)
  • Obesitydue togene mutationsrc homology 2B adaptor signaling protein(SH2B1)

Related codes at this level

Codes that share E88.8. If E88.82 is not quite right, the correct code is usually one of these.

Questions about E88.82

Is E88.82 a billable ICD-10-CM code?
Yes. E88.82 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E88.82 sit in the tabular list?
Endocrine, nutritional and metabolic diseases (E00-E89), in the block Metabolic disorders (E70-E88).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.