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E85.3

E85.3: Secondary systemic amyloidosis

Billable / specific codeICD-10-CM

E85.3 is a billable, specific ICD-10-CM code for secondary systemic amyloidosis. It is valid for submission on a claim.

Check E85.3 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Hemodialysis-associated amyloidosis

Excludes2 inherited from the categories above E85.3

Not part of this code, but both may be coded when both are present.

Written on E85: Amyloidosis

  • Alzheimer's disease (G30.0-)

Other codes that can never be billed with E85.3

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E27.1Primary adrenocortical insufficiency

Risk adjustment

E85.3 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 50 Amyloidosis, Porphyria, and Other Specified Metabolic Disorders0.648 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score. Look up the whole chart to see which of its HCCs the hierarchy would zero.

Medicare coverage

E85.3 is named in 30 Medicare coverage policies: 30 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52850Billing and Coding: Cardiac Catheterization and Coronary Angiography
  • A52996Billing and Coding: Routine Foot Care
  • A54954Billing and Coding: Autonomic Function Tests
  • A55336Billing and Coding: Retroperitoneal Ultrasound

Alphabetic index entries that lead here

  • Amyloidosis›hemodialysis-associated
  • Amyloidosis›secondary systemic

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E85

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.