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E27.1

E27.1Primary adrenocortical insufficiency

Billable / specific codeICD-10-CM

E27.1 is a billable, specific ICD-10-CM code for primary adrenocortical insufficiency. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • Addison only phenotype adrenoleukodystrophy (E71.528)
  • amyloidosis (E85.-)
  • tuberculous Addison's disease (A18.7)
  • Waterhouse-Friderichsen syndrome (A39.1)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Addison's disease
  • Autoimmune adrenalitis

Risk adjustment

E27.1 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 51 Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders0.510 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

E27.1 is named in 3 Medicare coverage policies 3 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A57326Billing and Coding: Electrocardiograms
  • A57361Billing and Coding: Monitored Anesthesia Care
  • A59186Billing and Coding: Magnesium

How E27.1 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E27.1.

  • Addison'sdisease or syndrome(bronze)
  • Adrenalitis, adrenitisautoimmune
  • Disease, diseasedbronze Addison's
  • Hypoadrenalism, hypoadreniaprimary
  • Hypoadrenocorticismprimary
  • Melanosisaddisonian
  • Melanosisadrenal
  • Melanosissuprarenal
  • Melasmaadrenal(gland)
  • Melasmasuprarenal(gland)
  • Atrophy, atrophicadrenalprimary(autoimmune)
  • Atrophy, atrophicsuprarenalprimary

Related codes at this level

Codes that share E27. If E27.1 is not quite right, the correct code is usually one of these.

Questions about E27.1

Is E27.1 a billable ICD-10-CM code?
Yes. E27.1 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E27.1 sit in the tabular list?
Endocrine, nutritional and metabolic diseases (E00-E89), in the block Disorders of other endocrine glands (E20-E35).
What cannot be coded together with E27.1?
E27.1 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.