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E85.0

E85.0: Non-neuropathic heredofamilial amyloidosis

Billable / specific codeICD-10-CM

E85.0 is a billable, specific ICD-10-CM code for non-neuropathic heredofamilial amyloidosis. It is valid for submission on a claim.

Check E85.0 with the rest of the claim: free scrubber

Excludes2: not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • Transthyretin-related (ATTR) familial amyloid cardiomyopathy (E85.4)

Code also

Both codes may be needed to describe the encounter fully. Sequencing depends on the reason for the visit.

  • associated disorders, such as:
  • autoinflammatory syndromes (M04.-)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Hereditary amyloid nephropathy

Excludes2 inherited from the categories above E85.0

Not part of this code, but both may be coded when both are present.

Written on E85: Amyloidosis

  • Alzheimer's disease (G30.0-)

Other codes that can never be billed with E85.0

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • K65Peritonitis
  • E27.1Primary adrenocortical insufficiency

Risk adjustment

E85.0 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 50 Amyloidosis, Porphyria, and Other Specified Metabolic Disorders0.648 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score. Look up the whole chart to see which of its HCCs the hierarchy would zero.

Medicare coverage

E85.0 is named in 22 Medicare coverage policies: 22 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A54954Billing and Coding: Autonomic Function Tests
  • A55336Billing and Coding: Retroperitoneal Ultrasound
  • A56232Billing and Coding: Foot Care
  • A56421Billing and Coding: CT of the Abdomen and Pelvis

Alphabetic index entries that lead here

  • Amyloidosis›non-neuropathic heredofamilial
  • Nephropathy›amyloid, hereditary
  • Peritonitis›paroxysmal, familial
  • Peritonitis›periodic, familial
  • Polyserositis›periodic, familial
  • Myopathy›in›amyloidosis
  • Peritonitis›paroxysmal, familial›benign

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E85

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.