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E85.0

E85.0Non-neuropathic heredofamilial amyloidosis

Billable / specific codeICD-10-CM

E85.0 is a billable, specific ICD-10-CM code for non-neuropathic heredofamilial amyloidosis. It is valid for submission on a claim.

Excludes2 — not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • Transthyretin-related (ATTR) familial amyloid cardiomyopathy (E85.4)

Code also

Both codes may be needed to describe the encounter fully. Sequencing depends on the reason for the visit.

  • associated disorders, such as:
  • autoinflammatory syndromes (M04.-)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Hereditary amyloid nephropathy

Other codes that can never be billed with E85.0

These codes carry an Excludes1 note pointing at E85.0. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading E85.0 alone.

Risk adjustment

E85.0 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 50 Amyloidosis, Porphyria, and Other Specified Metabolic Disorders0.648 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

E85.0 is named in 23 Medicare coverage policies 23 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A54954Billing and Coding: Autonomic Function Tests
  • A55336Billing and Coding: Retroperitoneal Ultrasound
  • A56232Billing and Coding: Foot Care
  • A56421Billing and Coding: CT of the Abdomen and Pelvis

How E85.0 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E85.0.

  • Amyloidosisnon-neuropathic heredofamilial
  • Nephropathyamyloid, hereditary
  • Peritonitisparoxysmal, familial
  • Peritonitisperiodic, familial
  • Polyserositisperiodic, familial
  • Myopathyinamyloidosis
  • Peritonitisparoxysmal, familialbenign

Related codes at this level

Codes that share E85. If E85.0 is not quite right, the correct code is usually one of these.

Questions about E85.0

Is E85.0 a billable ICD-10-CM code?
Yes. E85.0 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E85.0 sit in the tabular list?
Endocrine, nutritional and metabolic diseases (E00-E89), in the block Metabolic disorders (E70-E88).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.