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E78.2

E78.2: Mixed hyperlipidemia

Billable / specific codeICD-10-CM

E78.2 is a billable, specific ICD-10-CM code for mixed hyperlipidemia. It is valid for submission on a claim.

Check E78.2 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5)
  • familial combined hyperlipidemia (E78.49)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Broad- or floating-betalipoproteinemia
  • Combined hyperlipidemia NOS
  • Elevated cholesterol with elevated triglycerides NEC
  • Fredrickson's hyperlipoproteinemia, type IIb or III
  • Hyperbetalipoproteinemia with prebetalipoproteinemia
  • Hypercholesteremia with endogenous hyperglyceridemia
  • Hyperlipidemia, group C
  • Tubo-eruptive xanthoma
  • Xanthoma tuberosum

Excludes1 inherited from the categories above E78.2

A category’s note binds every code beneath it.

Written on E78: Disorders of lipoprotein metabolism and other lipidemias

Other codes that can never be billed with E78.2

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • M67Other disorders of synovium and tendon

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E78.2 is named in 17 Medicare coverage policies: 17 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56416Billing and Coding: Assays for Vitamins and Metabolic Function
  • A56422Billing and Coding: Bariatric Surgical Management of Morbid Obesity
  • A56675Billing and Coding: Homocysteine Level, Serum
  • A56943Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment

Alphabetic index entries that lead here

  • Betalipoproteinemia, broad or floating
  • Broad- or floating-betalipoproteinemia
  • Dysbetalipoproteinemia(familial)
  • Xanthelasmatosis(essential)
  • Xanthoma(s), xanthomatosis (primary) (familial) (hereditary)
  • Broad›beta disease
  • Frederickson's hyperlipoproteinemia, type›IIB and III
  • Hyperbetalipoproteinemia›with prebetalipoproteinemia
  • Hypercholesterolemia›with hyperglyceridemia, endogenous
  • Hyperlipemia, hyperlipidemia›combined
  • Hyperlipemia, hyperlipidemia›mixed
  • Lipoproteinemia›broad-beta

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E78

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.