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E78.49

E78.49Other hyperlipidemia

Billable / specific codeICD-10-CM

E78.49 is a billable, specific ICD-10-CM code for other hyperlipidemia. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Familial combined hyperlipidemia

Other codes that can never be billed with E78.49

These codes carry an Excludes1 note pointing at E78.49. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading E78.49 alone.

  • E78.2Mixed hyperlipidemia

Risk adjustment

E78.49 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

E78.49 is named in 12 Medicare coverage policies 12 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A56416Billing and Coding: Assays for Vitamins and Metabolic Function
  • A56422Billing and Coding: Bariatric Surgical Management of Morbid Obesity
  • A56675Billing and Coding: Homocysteine Level, Serum
  • A56943Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment

How E78.49 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E78.49.

  • Hyperlipemia, hyperlipidemiaspecified NEC
  • Hyperlipemia, hyperlipidemiacombinedfamilial

Related codes at this level

Codes that share E78.4. If E78.49 is not quite right, the correct code is usually one of these.

Questions about E78.49

Is E78.49 a billable ICD-10-CM code?
Yes. E78.49 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E78.49 sit in the tabular list?
Endocrine, nutritional and metabolic diseases (E00-E89), in the block Metabolic disorders (E70-E88).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.