MCMCB Pro
D89.83

D89.83Cytokine release syndrome

Non-billable headerICD-10-CM

D89.83 is a non-billable header ICD-10-CM code for cytokine release syndrome. It cannot be billed on its own: choose one of the more specific child codes below.

Code first

The underlying condition must be sequenced before this code.

  • underlying cause, such as:
  • complications following infusion, transfusion and therapeutic injection (T80.89-)
  • complications of transplanted organs and tissue (T86.-)

Use additional code

Add a secondary code to capture the detail described below.

  • code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
  • code to identify associated manifestations

Risk adjustment

D89.83 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Code to one of these instead D89.83

6 child codes. Green means billable.

Related codes at this level

Codes that share D89.8. If D89.83 is not quite right, the correct code is usually one of these.

Questions about D89.83

Is D89.83 a billable ICD-10-CM code?
No. D89.83 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does D89.83 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.