D89.83

D89.83: Cytokine release syndrome

Non-billable headerICD-10-CM

D89.83 is a non-billable header ICD-10-CM code for cytokine release syndrome. It cannot be billed on its own: choose one of the more specific child codes below.

Code first

The underlying condition must be sequenced before this code.

underlying cause, such as:
complications following infusion, transfusion and therapeutic injection (T80.89-)
complications of transplanted organs and tissue (T86.-)

Use additional code

Add a secondary code to capture the detail described below.

code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
code to identify associated manifestations

Excludes1 inherited from the categories above D89.83

A category’s note binds every code beneath it.

Written on D89: Other disorders involving the immune mechanism, not elsewhere classified

hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes2 inherited from the categories above D89.83

Not part of this code, but both may be coded when both are present.

Written on D89: Other disorders involving the immune mechanism, not elsewhere classified

transplant failure and rejection (T86.-)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead D89.83

6 child codes. Green means billable.