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D89.839

D89.839: Cytokine release syndrome, grade unspecified

Billable / specific codeICD-10-CM

D89.839 is a billable, specific ICD-10-CM code for cytokine release syndrome, grade unspecified. It is valid for submission on a claim.

Check D89.839 with the rest of the claim: free scrubber

Excludes1 inherited from the categories above D89.839

A category’s note binds every code beneath it.

Written on D89: Other disorders involving the immune mechanism, not elsewhere classified

  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes2 inherited from the categories above D89.839

Not part of this code, but both may be coded when both are present.

Written on D89: Other disorders involving the immune mechanism, not elsewhere classified

  • transplant failure and rejection (T86.-)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

D89.839 is named in 4 Medicare coverage policies: 4 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A55717Billing and Coding: Lab: Flow Cytometry
  • A56464Billing and Coding: Flow Cytometry
  • A56718Billing and Coding: Intravenous Immunoglobulin (IVIG)
  • A57718Billing and Coding: Vitamin D Assay Testing

Alphabetic index entries that lead here

  • Syndrome›cytokine release

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D89.83

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.