Is D89.833 a billable ICD-10-CM code?

Yes. D89.833 is a billable, specific ICD-10-CM code and is valid for submission on a claim.

Where does D89.833 sit in the tabular list?

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).

What cannot be coded together with D89.833?

D89.833 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above D89.833 (D89) and apply to it just the same.

D89.833

D89.833 — Cytokine release syndrome, grade 3

Billable / specific codeICD-10-CM

D89.833 is a billable, specific ICD-10-CM code for cytokine release syndrome, grade 3. It is valid for submission on a claim.

Excludes1 inherited from the categories above D89.833

These are not written on D89.833, but they bind it: a note on a category applies to every code beneath it. Billing D89.833 with anything listed here is a denial.

Written on D89 — Other disorders involving the immune mechanism, not elsewhere classified

hyperglobulinemia NOS (R77.1)
monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes2 inherited from the categories above D89.833

Also inherited, and the opposite of Excludes1: these conditions are not part of D89.833, but a patient can have both, so you may code both.

Written on D89 — Other disorders involving the immune mechanism, not elsewhere classified

transplant failure and rejection (T86.-)

Risk adjustment

D89.833 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D89.833 is named in 5 Medicare coverage policies — 5 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

A55717Billing and Coding: Lab: Flow Cytometry
A56464Billing and Coding: Flow Cytometry
A56718Billing and Coding: Intravenous Immunoglobulin (IVIG)
A57689Billing and Coding: Lab: Flow Cytometry

How D89.833 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D89.833.

Syndrome›cytokine release›grade 3

Code history

D89.833 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share D89.83. If D89.833 is not quite right, the correct code is usually one of these.

Questions about D89.833

Is D89.833 a billable ICD-10-CM code?: Yes. D89.833 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D89.833 sit in the tabular list?: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).
What cannot be coded together with D89.833?: D89.833 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above D89.833 (D89) and apply to it just the same.