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D59.2

D59.2Drug-induced nonautoimmune hemolytic anemia

Billable / specific codeICD-10-CM

D59.2 is a billable, specific ICD-10-CM code for drug-induced nonautoimmune hemolytic anemia. It is valid for submission on a claim.

Use additional code

Add a secondary code to capture the detail described below.

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Drug-induced enzyme deficiency anemia

Other codes that can never be billed with D59.2

These codes carry an Excludes1 note pointing at D59.2. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D59.2 alone.

  • D55Anemia due to enzyme disorders

Risk adjustment

D59.2 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D59.2 is named in 2 Medicare coverage policies 2 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A59105Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)
  • A60187Billing and Coding: Off-Label Use of Intravenous Immune Globulin (IVIG)

How D59.2 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D59.2.

  • Anemiaenzyme-deficiency, drug-induced
  • Nonautoimmune hemolytic anemiadrug-induced
  • Disease, diseasednonautoimmune hemolyticdrug-induced
  • Anemiadeficiencyenzymedrug-induced(hemolytic)
  • Anemiahemolyticdue todrugs(nonautoimmune)
  • Anemiahemolyticnonautoimmunedrug-induced
  • Anemiahemolyticdue toenzyme disorderdrug-induced

Related codes at this level

Codes that share D59. If D59.2 is not quite right, the correct code is usually one of these.

Questions about D59.2

Is D59.2 a billable ICD-10-CM code?
Yes. D59.2 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D59.2 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Hemolytic anemias (D55-D59).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.