MCMedicalCodingSoftware
D55.21

D55.21: Anemia due to pyruvate kinase deficiency

Billable / specific codeICD-10-CM

D55.21 is a billable, specific ICD-10-CM code for anemia due to pyruvate kinase deficiency. It is valid for submission on a claim.

Check D55.21 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • PK deficiency anemia
  • Pyruvate kinase deficiency anemia

Excludes1 inherited from the categories above D55.21

A category’s note binds every code beneath it.

Written on D55.2: Anemia due to disorders of glycolytic enzymes

  • disorders of glycolysis not associated with anemia (E74.81-)

Written on D55: Anemia due to enzyme disorders

  • drug-induced enzyme deficiency anemia (D59.2)

Other codes that can never be billed with D55.21

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E74.4Disorders of pyruvate metabolism and gluconeogenesis

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

D55.21 is named in 1 Medicare coverage policy: 1 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56718Billing and Coding: Intravenous Immunoglobulin (IVIG)

Alphabetic index entries that lead here

  • Anemia›pyruvate kinase deficiency
  • Anemia›deficiency›PK
  • Anemia›deficiency›pyruvate kinase
  • Anemia›hemolytic›nonspherocytic›congenital or hereditary NEC›pyruvate kinase deficiency

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D55.2

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.