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T80.52XD

T80.52XDAnaphylactic reaction due to vaccination, subsequent encounter

Billable / specific codeICD-10-CMPOA exempt

T80.52XD is a billable, specific ICD-10-CM code for anaphylactic reaction due to vaccination, subsequent encounter. It is valid for submission on a claim.

7th character "D" — subsequent encounter

The appropriate 7th character is to be added to each code from category T80

A
initial encounter
D
subsequent encounter
S
sequela

Excludes1 inherited from the categories above T80.52XD

These are not written on T80.52XD, but they bind it: a note on a category applies to every code beneath it. Billing T80.52XD with anything listed here is a denial.

Written on T80.5 Anaphylactic reaction due to serum

  • ABO incompatibility reaction due to transfusion of blood or blood products (T80.3-)
  • allergic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock NOS (T78.2)
  • anaphylactic reaction or shock due to adverse effect of correct medicinal substance properly administered (T88.6)
  • other serum reaction (T80.6-)

Excludes2 inherited from the categories above T80.52XD

Also inherited, and the opposite of Excludes1: these conditions are not part of T80.52XD, but a patient can have both, so you may code both.

Written on T80 Complications following infusion, transfusion and therapeutic injection

  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)

Risk adjustment

T80.52XD does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

T80.52XD is named in 18 Medicare coverage policies 18 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A53058Billing and Coding: Home Health Physical Therapy
  • A53065Billing and Coding: Outpatient Physical Therapy
  • A56538Billing and Coding: Allergen Immunotherapy
  • A56558Billing and Coding: Allergy Testing

Code history

T80.52XD has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share T80.52. If T80.52XD is not quite right, the correct code is usually one of these.

Questions about T80.52XD

Is T80.52XD a billable ICD-10-CM code?
Yes. T80.52XD is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does T80.52XD sit in the tabular list?
Injury, poisoning and certain other consequences of external causes (S00-T88), in the block Complications of surgical and medical care, not elsewhere classified (T80-T88).
What cannot be coded together with T80.52XD?
T80.52XD carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above T80.52XD (T80.5) and apply to it just the same.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.