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R65.11

R65.11: Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

Billable / specific codeICD-10-CM

R65.11 is a billable, specific ICD-10-CM code for systemic inflammatory response syndrome (sirs) of non-infectious origin with acute organ dysfunction. It is valid for submission on a claim.

Check R65.11 with the rest of the claim: free scrubber

Use additional code

Add a secondary code to capture the detail described below.

  • code to identify specific acute organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory failure (J96.0-)
  • critical illness myopathy (G72.81)
  • critical illness polyneuropathy (G62.81)
  • disseminated intravascular coagulopathy [DIC] (D65)
  • encephalopathy (metabolic) (septic) (G93.41)
  • hepatic failure (K72.0-)

Excludes1 inherited from the categories above R65.11

A category’s note binds every code beneath it.

Written on R65.1: Systemic inflammatory response syndrome (SIRS) of non-infectious origin

  • sepsis- code to infection
  • severe sepsis (R65.2)

Risk adjustment

R65.11 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 2 Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock0.500 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score. Look up the whole chart to see which of its HCCs the hierarchy would zero.

Medicare coverage

R65.11 is named in 1 Medicare coverage policy: 1 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A57326Billing and Coding: Electrocardiograms

Alphabetic index entries that lead here

  • Syndrome›systemic inflammatory response›with acute organ dysfunction
  • System, systemic›inflammatory response syndrome›with acute organ dysfunction

The condition this code belongs to

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under R65.1

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.