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R65.2

R65.2: Severe sepsis

Non-billable headerICD-10-CM

R65.2 is a non-billable header ICD-10-CM code for severe sepsis. It cannot be billed on its own: choose one of the more specific child codes below.

Code first

The underlying condition must be sequenced before this code.

  • underlying infection, such as:
  • infection following a procedure (T81.4-)
  • infections following infusion, transfusion and therapeutic injection (T80.2-)
  • puerperal sepsis (O85)
  • sepsis following complete or unspecified spontaneous abortion (O03.87)
  • sepsis following ectopic and molar pregnancy (O08.82)
  • sepsis following incomplete spontaneous abortion (O03.37)
  • sepsis following (induced) termination of pregnancy (O04.87)
  • sepsis NOS (A41.9)

Use additional code

Add a secondary code to capture the detail described below.

  • code to identify specific acute organ dysfunction, such as:
  • acute kidney failure (N17.-)
  • acute respiratory failure (J96.0-)
  • critical illness myopathy (G72.81)
  • critical illness polyneuropathy (G62.81)
  • disseminated intravascular coagulopathy [DIC] (D65)
  • encephalopathy (metabolic) (septic) (G93.41)
  • hepatic failure (K72.0-)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Infection with associated acute organ dysfunction
  • Sepsis with acute organ dysfunction
  • Sepsis with multiple organ dysfunction
  • Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction

Other codes that can never be billed with R65.2

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • R65.1Systemic inflammatory response syndrome (SIRS) of non-infectious origin
  • T79.4Traumatic shock
  • T79.4XXATraumatic shock, initial encounter
  • T79.4XXDTraumatic shock, subsequent encounter
  • T79.4XXSTraumatic shock, sequela

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

The condition this code belongs to

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead R65.2

2 child codes. Green means billable.

Other codes under R65

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.