Is R65.10 a billable ICD-10-CM code?

Yes. R65.10 is a billable, specific ICD-10-CM code and is valid for submission on a claim.

Where does R65.10 sit in the tabular list?

Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99), in the block General symptoms and signs (R50-R69).

What cannot be coded together with R65.10?

R65.10 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above R65.10 (R65.1) and apply to it just the same.

R65.10

R65.10 — Systemic inflammatory response syndrome (SIRS) of non-infectious origin without acute organ dysfunction

Billable / specific codeICD-10-CM

R65.10 is a billable, specific ICD-10-CM code for systemic inflammatory response syndrome (sirs) of non-infectious origin without acute organ dysfunction. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

Systemic inflammatory response syndrome (SIRS) NOS

Excludes1 inherited from the categories above R65.10

These are not written on R65.10, but they bind it: a note on a category applies to every code beneath it. Billing R65.10 with anything listed here is a denial.

Written on R65.1 — Systemic inflammatory response syndrome (SIRS) of non-infectious origin

sepsis- code to infection
severe sepsis (R65.2)

Risk adjustment

R65.10 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

HCC 2 Septicemia, Sepsis, Systemic Inflammatory Response Syndrome/Shock0.500 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

R65.10 is named in 1 Medicare coverage policy — 1 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

A57326Billing and Coding: Electrocardiograms

How R65.10 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to R65.10.

Syndrome›systemic inflammatory response(SIRS), of non-infectious origin (without organ dysfunction)
System, systemic›inflammatory response syndrome(SIRS) of non-infectious origin (without organ dysfunction)

The condition this code belongs to

Every code for the condition on one page, which one applies when, and the mistake coders make with it.

Sepsis ICD-10 codes

Code history

R65.10 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share R65.1. If R65.10 is not quite right, the correct code is usually one of these.

R65.11Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction

Questions about R65.10

Is R65.10 a billable ICD-10-CM code?: Yes. R65.10 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does R65.10 sit in the tabular list?: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99), in the block General symptoms and signs (R50-R69).
What cannot be coded together with R65.10?: R65.10 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above R65.10 (R65.1) and apply to it just the same.