Is E88.12 a billable ICD-10-CM code?

Yes. E88.12 is a billable, specific ICD-10-CM code and is valid for submission on a claim.

Where does E88.12 sit in the tabular list?

Endocrine, nutritional and metabolic diseases (E00-E89), in the block Metabolic disorders (E70-E88).

What cannot be coded together with E88.12?

E88.12 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above E88.12 (E88.1, E88) and apply to it just the same.

E88.12

E88.12 — Generalized lipodystrophy

Billable / specific codeICD-10-CM

E88.12 is a billable, specific ICD-10-CM code for generalized lipodystrophy. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

Acquired generalized lipodystrophy (AGL)
Berardinelli-Siep syndrome
Congenital generalized lipodystrophy (CGL)
Lawrence syndrome

Excludes1 inherited from the categories above E88.12

These are not written on E88.12, but they bind it: a note on a category applies to every code beneath it. Billing E88.12 with anything listed here is a denial.

Written on E88.1 — Lipodystrophy, not elsewhere classified

Whipple's disease (K90.81)

Written on E88 — Other and unspecified metabolic disorders

histiocytosis X (chronic) (C96.6)

Risk adjustment

E88.12 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

E88.12 is named in 2 Medicare coverage policies — 2 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

A57326Billing and Coding: Electrocardiograms
A59299Billing and Coding: Cosmetic and Reconstructive Surgery

How E88.12 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E88.12.

AGL(acquired generalized lipodystrophy)
CGL(congenital generalized lipodystrophy)
Lipodystrophy›generalized(acquired) (congenital)
Syndrome›Berardinelli-Siep
Syndrome›Lawrence

Code history

What changed, and when. Derived by diffing consecutive CMS release files — which matters when you are defending a code assigned under an earlier edition.

addedFY2024-FY2026
Generalized lipodystrophy

Related codes at this level

Codes that share E88.1. If E88.12 is not quite right, the correct code is usually one of these.

Questions about E88.12

Is E88.12 a billable ICD-10-CM code?: Yes. E88.12 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E88.12 sit in the tabular list?: Endocrine, nutritional and metabolic diseases (E00-E89), in the block Metabolic disorders (E70-E88).
What cannot be coded together with E88.12?: E88.12 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above E88.12 (E88.1, E88) and apply to it just the same.