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E21.1

E21.1: Secondary hyperparathyroidism, not elsewhere classified

Billable / specific codeICD-10-CM

E21.1 is a billable, specific ICD-10-CM code for secondary hyperparathyroidism, not elsewhere classified. It is valid for submission on a claim.

Check E21.1 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • secondary hyperparathyroidism of renal origin (N25.81)

Excludes1 inherited from the categories above E21.1

A category’s note binds every code beneath it.

Written on E21: Hyperparathyroidism and other disorders of parathyroid gland

  • adult osteomalacia (M83.-)
  • ectopic hyperparathyroidism (E34.2)
  • hungry bone syndrome (E83.81)
  • infantile and juvenile osteomalacia (E55.0)

Excludes2 inherited from the categories above E21.1

Not part of this code, but both may be coded when both are present.

Written on E21: Hyperparathyroidism and other disorders of parathyroid gland

  • familial hypocalciuric hypercalcemia (E83.52)

Other codes that can never be billed with E21.1

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • N25.81Secondary hyperparathyroidism of renal origin

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E21.1 is named in 12 Medicare coverage policies: 12 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56416Billing and Coding: Assays for Vitamins and Metabolic Function
  • A56798Billing and Coding: Vitamin D Assay Testing
  • A56841Billing and Coding: Vitamin D; 25 hydroxy, includes fraction(s), if performed
  • A57122Billing and Coding: Parathormone (Parathyroid Hormone)

Alphabetic index entries that lead here

  • Osteodystrophy›parathyroid, secondary
  • Hyperparathyroidism›secondary›non-renal

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E21

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.