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E21

E21: Hyperparathyroidism and other disorders of parathyroid gland

Non-billable headerICD-10-CM

E21 is a non-billable header ICD-10-CM code for hyperparathyroidism and other disorders of parathyroid gland. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • adult osteomalacia (M83.-)
  • ectopic hyperparathyroidism (E34.2)
  • hungry bone syndrome (E83.81)
  • infantile and juvenile osteomalacia (E55.0)

Excludes2: not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • familial hypocalciuric hypercalcemia (E83.52)

Other codes that can never be billed with E21

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E83.5Disorders of calcium metabolism
  • M85.6Other cyst of bone
  • N25.81Secondary hyperparathyroidism of renal origin
  • E83Disorders of mineral metabolism

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead E21

6 child codes. Green means billable.

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.